Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the 13C‐octanoate breath test
Identifieur interne : 000194 ( Main/Exploration ); précédent : 000193; suivant : 000195Patients with idiopathic rapid‐eye‐movement sleep behavior disorder show normal gastric motility assessed by the 13C‐octanoate breath test
Auteurs : Marcus M. Unger [Allemagne] ; Jens C. Möller [Allemagne] ; Katharina Mankel [Allemagne] ; Katrin Schmittinger [Allemagne] ; Karla M. Eggert [Allemagne] ; Maria Stamelou [Allemagne] ; Karin Stiasny-Kolster [Allemagne] ; Katharina Bohne [Allemagne] ; Maren Bodden [Allemagne] ; Geert Mayer [Allemagne] ; Wolfgang H. Oertel [Allemagne] ; Johannes J. Tebbe [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-12.
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Abstract
Background:: Delayed gastric emptying is a non‐motor symptom of Parkinson's disease. Few data exist on gastric emptying in early‐stage Parkinson's disease. In idiopathic rapid‐eye‐movement sleep behavior disorder, a presumable pre‐motor stage of Parkinson's disease, gastric emptying has not yet been investigated. Methods:: Twenty healthy controls, 13 patients with idiopathic rapid‐eye‐movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the 13C‐octanoate breath test. Results:: Gastric emptying was significantly delayed in drug‐naïve (P < .001) and in treated Parkinson's disease patients (P < .001), but normal in patients with idiopathic rapid‐eye‐movement sleep behavior disorder. Conclusions:: Our study confirms delayed gastric emptying in drug‐naïve, early‐stage Parkinson's disease. Normal gastric emptying in idiopathic rapid‐eye‐movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the 13C‐octanoate breath test. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23933
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Oertel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps‐University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Tebbe, Johannes J" sort="Tebbe, Johannes J" uniqKey="Tebbe J" first="Johannes J." last="Tebbe">Johannes J. Tebbe</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine, Philipps‐University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine, Division of Gastroenterology, Klinikum Lippe, Detmold</wicri:regionArea><wicri:noRegion>Detmold</wicri:noRegion><wicri:noRegion>Detmold</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12">2011-12</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2559">2559</biblScope><biblScope unit="page" to="2563">2563</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AC988CAD4A48DD46D1A5F6F7F08931A9B5D2714F</idno><idno type="DOI">10.1002/mds.23933</idno><idno type="ArticleID">MDS23933</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>13C‐octanoate breath test</term><term>PD</term><term>Parkinson's disease</term><term>RBD</term><term>REM sleep behavior disorder</term><term>gastric emptying</term><term>gastric motility</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Delayed gastric emptying is a non‐motor symptom of Parkinson's disease. Few data exist on gastric emptying in early‐stage Parkinson's disease. In idiopathic rapid‐eye‐movement sleep behavior disorder, a presumable pre‐motor stage of Parkinson's disease, gastric emptying has not yet been investigated. Methods:: Twenty healthy controls, 13 patients with idiopathic rapid‐eye‐movement sleep behavior disorder, and 39 patients with Parkinson's disease patients underwent standardized testing for gastric emptying with the 13C‐octanoate breath test. Results:: Gastric emptying was significantly delayed in drug‐naïve (P < .001) and in treated Parkinson's disease patients (P < .001), but normal in patients with idiopathic rapid‐eye‐movement sleep behavior disorder. Conclusions:: Our study confirms delayed gastric emptying in drug‐naïve, early‐stage Parkinson's disease. Normal gastric emptying in idiopathic rapid‐eye‐movement sleep behavior disorder might be explained by the fact that neurodegenerative changes in structures modulating gastric motility are not severe enough to cause a functional deficit that can be detected by the 13C‐octanoate breath test. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Unger, Marcus M" sort="Unger, Marcus M" uniqKey="Unger M" first="Marcus M." last="Unger">Marcus M. Unger</name></region><name sortKey="Bodden, Maren" sort="Bodden, Maren" uniqKey="Bodden M" first="Maren" last="Bodden">Maren Bodden</name><name sortKey="Bohne, Katharina" sort="Bohne, Katharina" uniqKey="Bohne K" first="Katharina" last="Bohne">Katharina Bohne</name><name sortKey="Eggert, Karla M" sort="Eggert, Karla M" uniqKey="Eggert K" first="Karla M." last="Eggert">Karla M. Eggert</name><name sortKey="Mankel, Katharina" sort="Mankel, Katharina" uniqKey="Mankel K" first="Katharina" last="Mankel">Katharina Mankel</name><name sortKey="Mayer, Geert" sort="Mayer, Geert" uniqKey="Mayer G" first="Geert" last="Mayer">Geert Mayer</name><name sortKey="Mayer, Geert" sort="Mayer, Geert" uniqKey="Mayer G" first="Geert" last="Mayer">Geert Mayer</name><name sortKey="Moller, Jens C" sort="Moller, Jens C" uniqKey="Moller J" first="Jens C." last="Möller">Jens C. Möller</name><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name><name sortKey="Schmittinger, Katrin" sort="Schmittinger, Katrin" uniqKey="Schmittinger K" first="Katrin" last="Schmittinger">Katrin Schmittinger</name><name sortKey="Stamelou, Maria" sort="Stamelou, Maria" uniqKey="Stamelou M" first="Maria" last="Stamelou">Maria Stamelou</name><name sortKey="Stiasny Olster, Karin" sort="Stiasny Olster, Karin" uniqKey="Stiasny Olster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><name sortKey="Tebbe, Johannes J" sort="Tebbe, Johannes J" uniqKey="Tebbe J" first="Johannes J." last="Tebbe">Johannes J. Tebbe</name><name sortKey="Tebbe, Johannes J" sort="Tebbe, Johannes J" uniqKey="Tebbe J" first="Johannes J." last="Tebbe">Johannes J. Tebbe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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